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          • Home
          • › Search Tool
          • › Search Results
          • › Mm00439616_m1
          See other IL10 GE Assays ›
          Gene Symbol:
          Il10
          Gene Name:
          interleukin 10
          Gene Aliases:
          CSIF, Il-10
          Chromosome Location:
          Chr.1: 131019845 - 131024970 on Build GRCm38
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          Assay ID Mm00439616_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (35)

          Genomic Map

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          Assay Details

          Gene Symbol: Il10
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_010548.2 NP_034678.1 3 - 4 445 85
          GenBank mRNA BC120612.1 - 3 - 4 420 40129535 85
          BC137844.1 - 3 - 4 420 8860863 85
          M37897.1 - 3 - 4 453 85

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          More Information


          Updated Mapping Information

          This assay targets the same location as MTA transcript cluster(s) TC0100001167.mm.1

          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Apoptosis Mammalian Gene Collection Mus musculus Mouse Chemokine Panel Mouse Immune Response Inventoried Mouse_Immune_Response Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Il10

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of cytokine production
          response to molecule of bacterial origin
          negative regulation of cytokine secretion involved in immune response
          negative regulation of chronic inflammatory response to antigenic stimulus
          positive regulation of B cell apoptotic process
          inflammatory response
          immune response
          regulation of gene expression
          negative regulation of myeloid dendritic cell activation
          negative regulation of B cell proliferation
          negative regulation of interferon-gamma production
          negative regulation of interleukin-12 production
          negative regulation of interleukin-6 production
          negative regulation of tumor necrosis factor production
          receptor biosynthetic process
          negative regulation of tumor necrosis factor biosynthetic process
          defense response to bacterium
          defense response to protozoan
          negative regulation of apoptotic process
          negative regulation of growth of symbiont in host
          negative regulation of nitric oxide biosynthetic process
          positive regulation of MHC class II biosynthetic process
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of JAK-STAT cascade
          positive regulation of cytokine secretion
          negative regulation of inflammatory response
          negative regulation of membrane protein ectodomain proteolysis
          positive regulation of sequence-specific DNA binding transcription factor activity
          response to glucocorticoid
          regulation of sensory perception of pain
          negative regulation of cytokine activity
          branching involved in labyrinthine layer morphogenesis
          cellular response to lipopolysaccharide
          cytokine activity
          interleukin-10 receptor binding

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Mouse Clariom S Array PSR0100009384.mm.1 NM_010548.2.1 Refseq
          Affymetrix Mouse Clariom S Array PSR0100009384.mm.1 NM_010548.2 Refseq
          Affymetrix Mouse Clariom S Array PSR0100009384.mm.1 TC0100001167.mm.1 MTA TC

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          Citations (35)

          Systemic PPARgamma ligation inhibits allergic immune response in the skin.
          Authors
          Dahten A, Koch C, Ernst D, Schnoller C, Hartmann S, Worm M
          Journal
          J Invest Dermatol - Page No 2211 (Mon Sep 01 00:00:00 EDT 2008)
          Volume (Year)
          128 (2008)
          Product Usage
          -
          Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.
          Authors
          Rocha FJ, Schleicher U, Mattner J, Alber G, Bogdan C
          Journal
          Infect Immun - Page No 3823 (Wed Aug 01 00:00:00 EDT 2007)
          Volume (Year)
          75 (2007)
          Product Usage
          -
          Early cytokine expression in mouse sciatic nerve after chronic constriction nerve injury depends on calpain.
          Authors
          Uceyler N, Tscharke A, Sommer C
          Journal
          Brain Behav Immun - Page No 553 (Sun Jul 01 00:00:00 EDT 2007)
          Volume (Year)
          21 (2007)
          Product Usage
          -
          Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice.
          Authors
          Chen Y, Boettger MK, Reif A, Schmitt A, Uceyler N, Sommer C
          Journal
          Mol Pain - Page No 13 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          6 (2010)
          Product Usage
          -
          Deletion of bradykinin B1 receptor reduces renal fibrosis.
          Authors
          Wang PH, Cenedeze MA, Campanholle G, Malheiros DM, Torres HA, Pesquero JB, Pacheco-Silva A, Camara NO
          Journal
          Int Immunopharmacol - Page No 653 (Mon Jun 01 00:00:00 EDT 2009)
          Volume (Year)
          9 (2009)
          Product Usage
          -
          Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators.
          Authors
          Osada Y, Shimizu S, Kumagai T, Yamada S, Kanazawa T
          Journal
          Int J Parasitol - Page No 457 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          39 (2009)
          Product Usage
          -
          The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
          Authors
          Huber JM, Tagwerker A, Heininger D, Mayer G, Rosenkranz AR, Eller K
          Journal
          Am J Physiol Renal Physiol - Page No F451 (Sat Aug 01 00:00:00 EDT 2009)
          Volume (Year)
          297 (2009)
          Product Usage
          -
          Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse.
          Authors
          Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF
          Journal
          Invest Ophthalmol Vis Sci - Page No 5019 (Fri Oct 01 00:00:00 EDT 2010)
          Volume (Year)
          51 (2010)
          Product Usage
          -
          Bacterial lipoproteins can disseminate from the periphery to inflame the brain.
          Authors
          Londono D, Cadavid D
          Journal
          Am J Pathol - Page No 2848 (Tue Jun 01 00:00:00 EDT 2010)
          Volume (Year)
          176 (2010)
          Product Usage
          -
          Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation: reversal by the anxiolytic chlordiazepoxide.
          Authors
          Curtin NM, Mills KH, Connor TJ
          Journal
          Brain Behav Immun - Page No 371 (Sun Mar 01 00:00:00 EST 2009)
          Volume (Year)
          23 (2009)
          Product Usage
          -
          Mutant alpha-synuclein overexpression mediates early proinflammatory activity.
          Authors
          Su X, Federoff HJ, Maguire-Zeiss KA
          Journal
          Neurotox Res - Page No 238 (Thu Oct 01 00:00:00 EDT 2009)
          Volume (Year)
          16 (2009)
          Product Usage
          -
          Differential effects of rapamycin in anti-GBM glomerulonephritis.
          Authors
          Hochegger K, Jansky GL, Soleiman A, Wolf AM, Tagwerker A, Seger C, Griesmacher A, Mayer G, Rosenkranz AR
          Journal
          J Am Soc Nephrol - Page No 1520 (Fri Aug 01 00:00:00 EDT 2008)
          Volume (Year)
          19 (2008)
          Product Usage
          -
          Effect of HeNe laser irradiation on extracellular matrix deposition and expression of cytokines and chemokines in paracoccidioidomycotic lesions.
          Authors
          Nagib PR, Gameiro J, da Costa TA, Di Gangi R, Ribeiro Jda S, Paulino LC, Verinaud L
          Journal
          Photochem Photobiol - Page No 920 (Thu Jul 01 00:00:00 EDT 2010)
          Volume (Year)
          86 (2010)
          Product Usage
          -
          Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve.
          Authors
          Uceyler N, Gobel K, Meuth SG, Ortler S, Stoll G, Sommer C, Wiendl H, Kleinschnitz C
          Journal
          Exp Neurol - Page No 153 (Mon Mar 01 00:00:00 EST 2010)
          Volume (Year)
          222 (2010)
          Product Usage
          -
          Kupffer cell-dependent TNF-alpha signaling mediates injury in the arterialized small-for-size liver transplantation in the mouse.
          Authors
          Tian Y, Jochum W, Georgiev P, Moritz W, Graf R, Clavien PA
          Journal
          Proc Natl Acad Sci U S A - Page No 4598 (Tue Mar 21 00:00:00 EST 2006)
          Volume (Year)
          103 (2006)
          Product Usage
          -
          Atorvastatin attenuates murine anti-glomerular basement membrane glomerulonephritis.
          Authors
          Eller P, Eller K, Wolf AM, Reinstadler SJ, Tagwerker A, Patsch JR, Mayer G, Rosenkranz AR
          Journal
          Kidney Int - Page No 428 (Mon Mar 01 00:00:00 EST 2010)
          Volume (Year)
          77 (2010)
          Product Usage
          -
          Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors.
          Authors
          Lucas JL, Mirshahpanah P, Haas-Stapleton E, Asadullah K, Zollner TM, Numerof RP
          Journal
          Cell Immunol - Page No 97 (Thu Jan 01 00:00:00 EST 2009)
          Volume (Year)
          257 (2009)
          Product Usage
          -
          Orally administered lactoperoxidase ameliorates dextran sulfate sodium-induced colitis in mice by up-regulating colonic interleukin-10 and maintaining peripheral regulatory T cells.
          Authors
          Shin K, Horigome A, Yamauchi K, Yaeshima T, Iwatsuki K
          Journal
          Int Immunopharmacol - Page No 1387 (Sun Nov 01 00:00:00 EDT 2009)
          Volume (Year)
          9 (2009)
          Product Usage
          -
          Modulation of acute diarrheal illness by persistent bacterial infection.
          Authors
          McBee ME, Zheng PZ, Rogers AB, Fox JG, Schauer DB
          Journal
          Infect Immun - Page No 4851 (Sat Nov 01 00:00:00 EDT 2008)
          Volume (Year)
          76 (2008)
          Product Usage
          -
          Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.
          Authors
          Stenzel W, Soltek S, Sanchez-Ruiz M, Akira S, Miletic H, Schluter D, Deckert M
          Journal
          Am J Pathol - Page No 132 (Tue Jan 01 00:00:00 EST 2008)
          Volume (Year)
          172 (2008)
          Product Usage
          -
          Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
          Authors
          Gitlin L, Benoit L, Song C, Cella M, Gilfillan S, Holtzman MJ, Colonna M
          Journal
          Plos Pathog - Page No e1000734 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          6 (2010)
          Product Usage
          -
          Topical delivery of silver nanoparticles promotes wound healing.
          Authors
          Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK
          Journal
          Chemmedchem - Page No 129 (Mon Jan 01 00:00:00 EST 2007)
          Volume (Year)
          2 (2007)
          Product Usage
          -
          Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice.
          Authors
          Kelly J, Ali Khan A, Yin J, Ferguson TA, Apte RS
          Journal
          J Clin Invest - Page No 3421 (Thu Nov 01 00:00:00 EDT 2007)
          Volume (Year)
          117 (2007)
          Product Usage
          -
          Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro.
          Authors
          Balga R, Wetterwald A, Portenier J, Dolder S, Mueller C, Hofstetter W
          Journal
          Bone - Page No 325 (Tue Aug 01 00:00:00 EDT 2006)
          Volume (Year)
          39 (2006)
          Product Usage
          -
          Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis.
          Authors
          Centonze D, Muzio L, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, D'Amelio M, Cavallucci V, Martorana A, Bergamaschi A, Cencioni MT, Diamantini A, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G
          Journal
          J Neurosci - Page No 3442 (Wed Mar 18 00:00:00 EDT 2009)
          Volume (Year)
          29 (2009)
          Product Usage
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          CD4(+)CD25 (+) Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model.
          Authors
          Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R
          Journal
          Dig Dis Sci - Page No (Thu Jun 03 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Regulation of the inflammatory response to Staphylococcus aureus-induced brain abscess by interleukin-10.
          Authors
          Stenzel W, Dahm J, Sanchez-Ruiz M, Miletic H, Hermann M, Courts C, Schwindt H, Utermohlen O, Schluter D, Deckert M
          Journal
          J Neuropathol Exp Neurol - Page No 1046 (Thu Dec 01 00:00:00 EST 2005)
          Volume (Year)
          64 (2005)
          Product Usage
          -
          Modulation of dendritic cell function by naive and regulatory CD4+ T cells.
          Authors
          Veldhoen M, Moncrieffe H, Hocking RJ, Atkins CJ, Stockinger B
          Journal
          J Immunol - Page No 6202 (Mon May 15 00:00:00 EDT 2006)
          Volume (Year)
          176 (2006)
          Product Usage
          -
          TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.
          Authors
          Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI
          Journal
          Innate Immun - Page No 205 (Sat Aug 01 00:00:00 EDT 2009)
          Volume (Year)
          15 (2009)
          Product Usage
          -
          CD8 T cells producing IL-17 and IFN-gamma initiate the innate immune response required for responses to antigen skin challenge.
          Authors
          Kish DD, Li X, Fairchild RL
          Journal
          J Immunol - Page No 5949 (Fri May 15 00:00:00 EDT 2009)
          Volume (Year)
          182 (2009)
          Product Usage
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          Beneficial effect of brewers' yeast extract on daily activity in a murine model of chronic fatigue syndrome.
          Authors
          Takahashi T, Yu F, Zhu SJ, Moriya J, Sumino H, Morimoto S, Yamaguchi N, Kanda T
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          3 (2006)
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          Administration of neural precursor cells ameliorates renal ischemia-reperfusion injury.
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          Wang PH, Schwindt TT, Barnabe GF, Motta FL, Semedo P, Beraldo FC, Mazzali M, Dos Reis MA, Teixeira Vde P, Pacheco-Silva A, Mello LE, Camara NO
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          Nephron Exp Nephrol - Page No e20 (Thu Jan 01 00:00:00 EST 2009)
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          112 (2009)
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          Topical omega-3 and omega-6 fatty acids for treatment of dry eye.
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          Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg DA, Dana MR
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          Arch Ophthalmol - Page No 219 (Fri Feb 01 00:00:00 EST 2008)
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          126 (2008)
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          IL-9 Production by Regulatory T Cells Recruits Mast Cells That Are Essential for Regulatory T Cell-Induced Immune Suppression.
          Authors
          Eller K, Wolf D, Huber JM, Metz M, Mayer G, McKenzie AN, Maurer M, Rosenkranz AR, Wolf AM
          Journal
          J Immunol - Page No (Mon Nov 29 00:00:00 EST 2010)
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           (2010)
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          Impact of systemic histamine deficiency on the crosstalk between mammary adenocarcinoma and T cells.
          Authors
          Hegyesi H, Colombo L, Pallinger E, Toth S, Boer K, Molnar V, Falus A
          Journal
          J Pharmacol Sci - Page No 66 (Sat Sep 01 00:00:00 EDT 2007)
          Volume (Year)
          105 (2007)
          Product Usage
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