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          • Home
          • › Search Tool
          • › Search Results
          • › Hs00174086_m1
          See other IL10 GE Assays ›
          Gene Symbol:
          IL10
          Gene Name:
          interleukin 10
          Gene Aliases:
          CSIF, GVHDS, IL-10, IL10A, TGIF
          Chromosome Location:
          Chr.1: 206767603 - 206772494 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00174086_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (29)

          Genomic Map

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          Assay Details

          Gene Symbol: IL10
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_000572.2 NP_000563.1 3 - 4 441 119
          GenBank mRNA AF043333.1 - 3 - 4 328 119
          AY029171.1 - 3 - 4 382 119
          BC104252.1 - 3 - 4 438 40035920 119
          BC104253.1 - 3 - 4 438 40035922 119
          CR541993.1 - 3 - 4 382 119
          M57627.1 - 3 - 4 412 119

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          More Information


          Updated Mapping Information

          This assay targets the same location as Clariom D transcript cluster(s) TC0100017107.hg.1
          This assay targets the same location as HTA transcript cluster(s) TC01003766.hg.1

          Set Membership:

          Ambion siRNA available Amplicon length greater than or equal to 101 Apoptosis Immune Tolerance Network Mammalian Gene Collection Homo sapiens Human Chemokine Panel Human Immune Response Human NFkB Pathway Human Diabetes Inventoried Human_Immune Human_Nfkb Human_Diabetes Human_Chemokine Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene IL10

          Gene Ontology Categories:

          Function(s) Process(es)

          response to molecule of bacterial origin
          negative regulation of cytokine secretion involved in immune response
          negative regulation of chronic inflammatory response to antigenic stimulus
          positive regulation of B cell apoptotic process
          inflammatory response
          cytoplasmic sequestering of NF-kappaB
          cell-cell signaling
          aging
          regulation of gene expression
          response to activity
          response to inactivity
          hemopoiesis
          B cell differentiation
          leukocyte chemotaxis
          negative regulation of myeloid dendritic cell activation
          negative regulation of B cell proliferation
          negative regulation of interferon-gamma production
          negative regulation of interleukin-1 production
          negative regulation of interleukin-12 production
          negative regulation of interleukin-18 production
          negative regulation of interleukin-6 production
          negative regulation of interleukin-8 production
          negative regulation of tumor necrosis factor production
          receptor biosynthetic process
          response to insulin
          response to carbon monoxide
          cellular response to hepatocyte growth factor stimulus
          type 2 immune response
          B cell proliferation
          negative regulation of T cell proliferation
          response to drug
          negative regulation of tumor necrosis factor biosynthetic process
          defense response to bacterium
          defense response to protozoan
          negative regulation of apoptotic process
          negative regulation of growth of symbiont in host
          negative regulation of nitric oxide biosynthetic process
          regulation of isotype switching
          negative regulation of MHC class II biosynthetic process
          positive regulation of MHC class II biosynthetic process
          negative regulation of interferon-alpha biosynthetic process
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of JAK-STAT cascade
          positive regulation of cytokine secretion
          negative regulation of membrane protein ectodomain proteolysis
          positive regulation of sequence-specific DNA binding transcription factor activity
          response to glucocorticoid
          regulation of sensory perception of pain
          negative regulation of cytokine activity
          branching involved in labyrinthine layer morphogenesis
          cellular response to lipopolysaccharide
          cellular response to estradiol stimulus
          negative regulation of chemokine (C-C motif) ligand 5 production
          regulation of complement-dependent cytotoxicity
          negative regulation of endothelial cell apoptotic process
          cytokine activity
          interleukin-10 receptor binding
          protein binding
          growth factor activity

          MicroArray Probes:

          Affymetrix

          Array Name Probe IDs Targets Target Type
          Affymetrix Human Transcriptome Array 2.0 PSR01057741.hg.1 TC01003766.hg.1 HTA TC
          Affymetrix Human Transcriptome Array 2.0 PSR01057741.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR01057741.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 PSR01057741.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Transcriptome Array 2.0 TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay PSR0100229692.hg.1 TC0100017107.hg.1 Clariom D TC
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000367099.3 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000423557.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 ENST00000471071.1 Ensembl
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq
          Affymetrix Human Clariom D Assay TC0100017107.hg.1 NM_000572.2 Refseq

          Back To Top
           

          Citations (29)

          The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
          Authors
          Scholz H, Lund T, Dahle MK, Collins JL, Korsgren O, Wang JE, Foss A
          Journal
          Diabetologia - Page No 1352 (Wed Jul 01 00:00:00 EDT 2009)
          Volume (Year)
          52 (2009)
          Product Usage
          -
          Intragraft expression of the IL-10 gene is up-regulated in renal protocol biopsies with early interstitial fibrosis, tubular atrophy, and subclinical rejection.
          Authors
          Hueso M, Navarro E, Moreso F, O'Valle F, Perez-Riba M, Del Moral RG, Grinyo JM, Seron D
          Journal
          Am J Pathol - Page No 1696 (Thu Apr 01 00:00:00 EDT 2010)
          Volume (Year)
          176 (2010)
          Product Usage
          -
          Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.
          Authors
          Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN, Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ
          Journal
          Eur Respir J - Page No (Fri Sep 03 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells.
          Authors
          Makela SM, Strengell M, Pietila TE, Osterlund P, Julkunen I
          Journal
          J Leukoc Biol - Page No 664 (Wed Apr 01 00:00:00 EDT 2009)
          Volume (Year)
          85 (2009)
          Product Usage
          -
          Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes.
          Authors
          Gandhi N, Saiyed Z, Thangavel S, Rodriguez J, Rao KV, Nair MP
          Journal
          Aids Res Hum Retroviruses - Page No 691 (Wed Jul 01 00:00:00 EDT 2009)
          Volume (Year)
          25 (2009)
          Product Usage
          -
          Inflammatory and microRNA Gene Expression as Prognostic Classifiers of Barrett's Associated Esophageal Adenocarcinoma.
          Authors
          Nguyen GH, Schetter AJ, Chou DB, Bowman ED, Zhao R, Hawkes JE, Mathe E, Kumamoto K, Zhao Y, Budhu A, Hagiwara N, Wang XW, Miyashita M, Casson AG, Harris CC
          Journal
          Clin Cancer Res - Page No (Mon Oct 25 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Remodeling phenotype of human subcutaneous adipose tissue macrophages.
          Authors
          Bourlier V, Zakaroff-Girard A, Miranville A, De Barros S, Maumus M, Sengenes C, Galitzky J, Lafontan M, Karpe F, Frayn KN, Bouloumie A
          Journal
          Circulation - Page No 806 (Tue Feb 12 00:00:00 EST 2008)
          Volume (Year)
          117 (2008)
          Product Usage
          -
          Role of the mTOR Pathway in LPS-Activated Monocytes: Influence of Hypertonic Saline.
          Authors
          Schaeffer V, Arbabi S, Garcia IA, Knoll ML, Cuschieri J, Bulger EM, Maier RV
          Journal
          J Surg Res - Page No (Wed Jun 09 00:00:00 EDT 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          New means to monitor the effect of glucocorticoid therapy in children.
          Authors
          Rintamaki H, Salo HM, Vaarala O, Kolho KL
          Journal
          World J Gastroenterol - Page No 1104 (Sun Mar 07 00:00:00 EST 2010)
          Volume (Year)
          16 (2010)
          Product Usage
          -
          cis-Urocanic acid initiates gene transcription in primary human keratinocytes.
          Authors
          Kaneko K, Smetana-Just U, Matsui M, Young AR, John S, Norval M, Walker SL
          Journal
          J Immunol - Page No 217 (Tue Jul 01 00:00:00 EDT 2008)
          Volume (Year)
          181 (2008)
          Product Usage
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          CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes.
          Authors
          Zbytek B, Slominski AT
          Journal
          J Invest Dermatol - Page No 730 (Thu Mar 01 00:00:00 EST 2007)
          Volume (Year)
          127 (2007)
          Product Usage
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          Differential expression patterns of cytokines in complex regional pain syndrome.
          Authors
          Uceyler N, Eberle T, Rolke R, Birklein F, Sommer C
          Journal
          Pain - Page No 195 (Thu Nov 01 00:00:00 EDT 2007)
          Volume (Year)
          132 (2007)
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          Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation.
          Authors
          Vlad G, Ho EK, Vasilescu ER, Fan J, Liu Z, Cai JW, Jin Z, Burke E, Deng M, Cadeiras M, Cortesini R, Itescu S, Marboe C, Mancini D, Suciu-Foca N
          Journal
          Transpl Immunol - Page No 13 (Sun Jul 01 00:00:00 EDT 2007)
          Volume (Year)
          18 (2007)
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          Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients.
          Authors
          Dijke IE, Velthuis JH, Caliskan K, Korevaar SS, Maat AP, Zondervan PE, Balk AH, Weimar W, Baan CC
          Journal
          Transplantation - Page No 1477 (Fri Jun 15 00:00:00 EDT 2007)
          Volume (Year)
          83 (2007)
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          Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients.
          Authors
          Suciu-Foca N, Feirt N, Zhang QY, Vlad G, Liu Z, Lin H, Chang CC, Ho EK, Colovai AI, Kaufman H, D'Agati VD, Thaker HM, Remotti H, Galluzzo S, Cinti P, Rabitti C, Allendorf J, Chabot J, Caricato M, Coppola R, Berloco P, Cortesini R
          Journal
          J Immunol - Page No 7432 (Fri Jun 01 00:00:00 EDT 2007)
          Volume (Year)
          178 (2007)
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          Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.
          Authors
          Keller CC, Yamo O, Ouma C, Ong'echa JM, Ounah D, Hittner JB, Vulule JM, Perkins DJ
          Journal
          Infect Immun - Page No 5249 (Fri Sep 01 00:00:00 EDT 2006)
          Volume (Year)
          74 (2006)
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          Postmenopausal expression changes of immune system-related genes in human bone tissue.
          Authors
          Kosa JP, Balla B, Kiss J, Podani J, Takacs I, Lazary A, Nagy Z, Bacsi K, Karsai A, Speer G, Lakatos P
          Journal
          J Clin Immunol - Page No 761 (Sun Nov 01 00:00:00 EDT 2009)
          Volume (Year)
          29 (2009)
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          Influence of interleukin-8 and interleukin-10 on sporadic colon cancer development and progression.
          Authors
          Cacev T, Radosevic S, Krizanac S, Kapitanovic S
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          Carcinogenesis - Page No 1572 (Fri Aug 01 00:00:00 EDT 2008)
          Volume (Year)
          29 (2008)
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          Molecular evidence of injury and inflammation in normal and fibrotic renal allografts one year posttransplant.
          Authors
          Park W, Griffin M, Grande JP, Cosio F, Stegall MD
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          Transplantation - Page No 1466 (Fri Jun 15 00:00:00 EDT 2007)
          Volume (Year)
          83 (2007)
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          Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists.
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          Kamgang RK, Ramos I, Rodrigues Duarte L, Ghielmetti M, Freudenberg M, Dahinden C, Padovan E
          Journal
          Med Microbiol Immunol - Page No 369 (Mon Dec 01 00:00:00 EST 2008)
          Volume (Year)
          197 (2008)
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          Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
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          Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF, Adikibi T, Pridgeon C, Dallman M, Loke TK, Robinson DS, Barrat FJ, O'Garra A, Lavender P, Lee TH, Corrigan C, Hawrylowicz CM
          Journal
          J Clin Invest - Page No 146 (Sun Jan 01 00:00:00 EST 2006)
          Volume (Year)
          116 (2006)
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          Effect of sialic acid loss on dendritic cell maturation.
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          Crespo HJ, Cabral MG, Teixeira AV, Lau JT, Trindade H, Videira PA
          Journal
          Immunology - Page No e621 (Tue Sep 01 00:00:00 EDT 2009)
          Volume (Year)
          128 (2009)
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          Gene expression by human monocytes from peripheral blood in response to exposure to metals.
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          Jost-Albrecht K, Hofstetter W
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          76 (2006)
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          Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells.
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          Slominski A, Zbytek B, Slominski R
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          Int J Cancer - Page No 1470 (Sun Mar 15 00:00:00 EDT 2009)
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          124 (2009)
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          High expression of Foxp3, IL-23p19 and survivin mRNA in colorectal carcinoma.
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          Stanilov N, Miteva L, Mintchev N, Stanilova S
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          Int J Colorectal Dis - Page No 151 (Sun Feb 01 00:00:00 EST 2009)
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          Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide.
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          Barksby HE, Nile CJ, Jaedicke KM, Taylor JJ, Preshaw PM
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          Clin Exp Immunol - Page No 479 (Mon Jun 01 00:00:00 EDT 2009)
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          156 (2009)
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          Myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of T-cell proliferation.
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          Bluth MJ, Zaba LC, Moussai D, Suarez-Farinas M, Kaporis H, Fan L, Pierson KC, White TR, Pitts-Kiefer A, Fuentes-Duculan J, Guttman-Yassky E, Krueger JG, Lowes MA, Carucci JA
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          J Invest Dermatol - Page No 2451 (Thu Oct 01 00:00:00 EDT 2009)
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          Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression.
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          Krakauer M, Sorensen P, Khademi M, Olsson T, Sellebjerg F
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          Local and systemic cytokine and chemokine responses after parenteral influenza vaccination.
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          Eriksson JC, Cox RJ, Szyszko E, Davidsson A, Brokstad KA
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          Volume (Year)
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