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Invitrogen
p27 Polyclonal Antibody
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Product Details
PA5-52634
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human p27. Recombinant protein control fragment (Product #RP-90226).
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645139
Product Specific Information
Immunogen sequence: ITFELPDNAK QCFYEDIAQG TKCTLEFQVI TGGHYDVDCR LEDPDGKVLY KEMKKQYDSF TFTASKNGTY KFCFSNEFST F
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.
Target Information
p27, also known as p27Kip1, is a crucial cyclin-dependent kinase inhibitor (CKI) involved in the regulation of the cell cycle. The p27 protein is encoded by the CDKN1B gene located on chromosome 12 and plays a vital role in controlling cell proliferation by inhibiting cyclin-CDK complexes, particularly cyclin A-CDK2 and cyclin E-CDK2. By regulating these complexes, p27 induces cell cycle arrest at the G1 phase, preventing cells from prematurely entering the S phase. This function is critical for maintaining normal cellular processes and preventing uncontrolled cell division. p27 acts as a tumor suppressor, and its expression is tightly controlled by transcriptional and post-transcriptional mechanisms, including proteasome-mediated degradation. Reduced levels of p27 have been associated with numerous cancers, highlighting its role in tumorigenesis. The regulation of p27 involves signaling pathways such as the PI3K/AKT pathway, impacting its localization and stability in response to extracellular signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p24 family protein gamma-3; p24gamma3; p27; Transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7
Gene Aliases: CGI-109; p24g3; p24gamma3; p27; TMED7
UniProt ID: (Human) Q9Y3B3
Entrez Gene ID: (Human) 51014
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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