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Invitrogen
p27 Polyclonal Antibody
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Product Details
PA5-28487
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human TMED7. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545963
Product Specific Information
Recommended positive controls: 293T, A431.
Predicted reactivity: Mouse (98%), Rat (100%), Zebrafish (89%), Xenopus laevis (91%), Dog (99%), Pig (99%), Rabbit (99%), Chicken (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
p27, also known as p27Kip1, is a crucial cyclin-dependent kinase inhibitor (CKI) involved in the regulation of the cell cycle. The p27 protein is encoded by the CDKN1B gene located on chromosome 12 and plays a vital role in controlling cell proliferation by inhibiting cyclin-CDK complexes, particularly cyclin A-CDK2 and cyclin E-CDK2. By regulating these complexes, p27 induces cell cycle arrest at the G1 phase, preventing cells from prematurely entering the S phase. This function is critical for maintaining normal cellular processes and preventing uncontrolled cell division. p27 acts as a tumor suppressor, and its expression is tightly controlled by transcriptional and post-transcriptional mechanisms, including proteasome-mediated degradation. Reduced levels of p27 have been associated with numerous cancers, highlighting its role in tumorigenesis. The regulation of p27 involves signaling pathways such as the PI3K/AKT pathway, impacting its localization and stability in response to extracellular signals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p24 family protein gamma-3; p24gamma3; p27; Transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7
Gene Aliases: CGI-109; p24g3; p24gamma3; p27; TMED7
UniProt ID: (Human) Q9Y3B3
Entrez Gene ID: (Human) 51014
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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