Exalpha

p130 Monoclonal Antibody (KAB40)

Product Details

N105M

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

KAB40

Immunogen

Recombinant protein to the N terminus of p130

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-2 mg/mL

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

This antibody recognizes both the phosphorylated and unphosphorylated forms of p130 at a MW of 130kDa. And is suitable for use in western blot with his- tagged or GST tagged proteins.

Target Information

RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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