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Invitrogen
mGluR2/mGluR3 Polyclonal Antibody
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Product Details
PA1-4732
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a portion of the C-terminus of the rat Metabotropic Glutamate Receptor 2/3
Conjugate
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PA1-4732 detects Metabotropic Glutamate Receptor 2/3 from rat samples.
PA1-4732 has been successfully used in Western blot and immunohistochemistry applications. PA1-4732 is specific for the ~110k monomer and the ~220k dimer of mGluR2 and mGluR3 in western blots of rat brain.
The PA1-4732 immunogen is a synthetic peptide corresponding to a portion the C-terminus of rat Metabotropic Glutamate Receptor 2/3
Target Information
The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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