Product References
SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation.
International journal of biological sciences
Han M,Guo Y,Li Y,Zeng Q,Zhu W,Jiang J
OSE00003G was used in Western Blot to reveal that the manipulation of ID2 via SMURF2 may control tumor progression and contribute to the development of novel targeted antitumor drugs.
Thu Aug 03 00:00:00 UTC 2023
Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression.
PLoS pathogens
Visser LJ,Aloise C,Swatek KN,Medina GN,Olek KM,Rabouw HH,de Groot RJ,Langereis MA,de Los Santos T,Komander D,Skern T,van Kuppeveld FJM
OSE00003G was used in Western Blotting to demonstrate that TBK1, the kinase that phosphorylates and activates the transcription factor IRF3, is cleaved by Lpro in FMDV-infected cells and cells infected with a recombinant EMCV expressing Lpro. In vitro cleavage experiments revealed that Lpro cleaves TBK1 at residues 692-694. We also observed cleavage of MAVS in HeLa cells infected with EMCV-Lpro, but only observed decreasing levels of MAVS in FMDV-infected porcine LFPK αVβ6 cells.
Wed Jul 01 00:00:00 UTC 2020
Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation.
Journal of virology
Visser LJ,Medina GN,Rabouw HH,de Groot RJ,Langereis MA,de Los Santos T,van Kuppeveld FJM
OSE00003G was used in Western Blotting to study the role of FMDV in the modulation of the integrated stress response.
Tue Jan 15 00:00:00 UTC 2019
Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells.
The Journal of clinical investigation
Barrott JJ,Illum BE,Jin H,Hedberg ML,Wang Y,Grossmann A,Haldar M,Capecchi MR,Jones KB
OSE00003G was used in Immunohistochemistry to explain the skeletal contact frequently observed in human SS and may provide alternate means of enabling SS18-SSX-driven oncogenesis in cells as differentiated as preosteoblasts.
Tue Jan 02 00:00:00 UTC 2018
A single nucleotide polymorphism in the Plasmodium falciparum atg18 gene associates with artemisinin resistance and confers enhanced parasite survival under nutrient deprivation.
Malaria journal
Breglio KF,Amato R,Eastman R,Lim P,Sa JM,Guha R,Ganesan S,Dorward DW,Klumpp-Thomas C,McKnight C,Fairhurst RM,Roberts D,Thomas C,Simon AK
OSE00003G was used in Electron microscopy experiments to suggest that the atg18 T38I polymorphism may provide additional resistance against artemisinin derivatives, but not partner drugs, even in the absence of kelch13 mutations, and may also be important in parasite survival during nutrient deprivation.
Fri Oct 26 00:00:00 UTC 2018
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage.
Journal of virology
Humoud MN,Doyle N,Royall E,Willcocks MM,Sorgeloos F,van Kuppeveld F,Roberts LO,Goodfellow IG,Langereis MA,Locker N
OSE00003G was used in western blot to study disruption of the assembly of cytoplasmic stress granules and induction of G3BP1 cleavage by feline calicivirus infection
Fri Jul 15 00:00:00 UTC 2016
Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development.
Development (Cambridge, England)
Tien CL,Jones A,Wang H,Gerigk M,Nozell S,Chang C
OSE00003G was used in ChIP assay to identify and study epigenetic mechanisms that contribute to neural crest development.
Sun Feb 15 00:00:00 UTC 2015
Acute and temporal expression of tumor necrosis factor (TNF)-α-stimulated gene 6 product, TSG6, in mesenchymal stem cells creates microenvironments required for their successful transplantation into muscle tissue.
The Journal of biological chemistry
Torihashi S,Ho M,Kawakubo Y,Komatsu K,Nagai M,Hirayama Y,Kawabata Y,Takenaka-Ninagawa N,Wanachewin O,Zhuo L,Kimata K
OSE00003G was used in Immunohistochemistry to investigate the microenvironments crucial for cell transplantation, using the lysate of C2C12 myotubules for mimicking injured circumstances in vivo.
Fri Sep 11 00:00:00 UTC 2015