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Proteintech
ZFYVE21 Polyclonal Antibody
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Product Details
24806-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ZFYVE21 Fusion Protein Ag20024 (1-234 aa encoded by BC001130)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSSEVSARR DAKKLVRSPS GLRMVPEHRA FGSPFGLEEP QWVPDKECRR CMQCDAKFDF LTRKHHCRRC GKCFCDRCCS QKVPLRRMCF VDPVRQCAEC ALVSLKEAEF YDKQLKVLLS GATFLVTFGN SEKPETMTCR LSNNQRYLFL DGDSHYEIEI VHISTVQILT EGFPPGGGNA RATGMFLQYT VPGTEGVTQL KLTVVEDVTV GRRQAVAWLV AMHKAAKLLY ESRDQ (1-234 aa encoded by BC001130)
Target Information
ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FYVE domain containing 21; HCV p7-transactivated protein 1; ZF21; Zinc finger FYVE domain-containing protein 21; zinc finger, FYVE domain containing 21
Gene Aliases: HCVP7TP1; ZF21; ZFYVE21
UniProt ID: (Human) Q9BQ24
Entrez Gene ID: (Human) 79038
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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