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Invitrogen
YTHDF2 Recombinant Rabbit Monoclonal Antibody (HL1355)
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FIGURE: 1 / 7
YTHDF2 Antibody (MA5-47011) in ICC/IF
Immunofluorescent analysis of YTHDF2 in HeLa cells. Cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: YTHDF2 stained by YTHDF2 monoclonal antibody (Product # MA5-47011) diluted at 1:500. Blue: Fluoroshield with DAPI Scale bar= 10 µm.
Product Details
MA5-47011
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1355
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human YTHDF2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938083
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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