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Invitrogen
WHIP Polyclonal Antibody
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FIGURE: 1 / 1
WHIP Antibody (PA1-29543) in WB
Western blot analysis is shown using GeneTex Affinity Purified anti-Human WHIP Polyclonal Antibody (Product # PA1-29543) to detect Human WHIP present in a HEK293 whole cell lysate. ~30 mg of lysate was loaded per lane for 4-20% gradient SDS-PAGE. Comparison to a molecular weight marker (not shown) indicates a primary band of ~96.0 kDa is detected. The identity of the minor band migrating at a slightly higher molecular weight is unknown, but may represent an alternate isoform of WHIP or post translational modification of the WHIP protein. T... View More
Product Details
PA1-29543
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide SRESYDAPPTPSGAC conjugated to KLH, corresponding to amino acids 107-120 of Human WHIP.
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2257260
Product Specific Information
PA1-29543 detects WHIP from human samples.
PA1-29543 has been successfully used in Western blot applications.
The PA1-29543 immunogen is: Synthetic peptide: SRESYDAPPTPSGAC conjugated to KLH, corresponding to amino acids 107-120 of Human WHIP.
Target Information
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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