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Invitrogen
WAC Polyclonal Antibody
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WAC Antibody (PA5-85683) in IHC (P)
WAC Polyclonal Antibody detects WAC protein at nucleus in mouse testis by immunohistochemical analysis. Sample: Paraffin-embedded mouse testis. WAC Polyclonal Antibody (Product # PA5-85683) diluted at 1:1,000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-85683
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human WAC.
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792822
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (94%), Rat (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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