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Invitrogen
Urokinase Monoclonal Antibody (U-6)
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FIGURE: 1 / 1
Urokinase Antibody (MON U-6-02) in IHC
Immunohistochemistry was performed on human primary invasive breast cancer tissue sections. Following tissue processing using a formalin-free, HEPES-glutamic acid buffer-mediated organic solvent protection effect fixation technique, tissues were blocked with 3% hydrogen peroxide for 10 minutes at room temperature. Tissues were probed with buffer alone as a negative control (panel A), a positive control Urokinase Plasminogen Activator monoclonal antibody, clone SPM457 (panel B), or Urokinase Plasminogen Activator monoclonal antibodies, Prod... View More
Product Details
MON U-6-02
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
U-6
Immunogen
Native human uPA.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Wet ice
RRID
AB_10980514
Product Specific Information
MON U-6-02 is specific for human uPA. No reaction with human tissue plasminogen activator (tPA) is seen when tested by ELISA, immunoblotting and enzyme inhibition. No reaction with any other human plasma proteins is seen when tested by immunoblotting.
MON U-6-02 has successfully been used in ELISA, Western blot and immunohistochemistry (frozen) applications.
The immunogen used to produce MON U-6-02 is native human uPA.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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