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Invitrogen
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Immunogen sequence: PSKVGKRCRKT SDPRRSIVEC QPDASATPGV GTADSPAAPT DSRDDQKGLS LSPQSPPERR GYPGPGLRSD WHASSPLLIT SDTEHVTLLS EAEHH
Highest antigen sequence identity to the following orthologs - mouse 44%, rat 43%.
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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