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Invitrogen
TYROBP Polyclonal Antibody
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FIGURE: 1 / 1
TYROBP Antibody (PA5-28803) in WB
Western Blot was performed using Anti-TYROBP Polyclonal Antibody (Product # PA5-28803) and a 12 and 11 kDa band corresponding to TYRO protein tyrosine kinase-binding protein, along with an uncharacterized band (*), was observed across positive model THP 1 differentiated to macrophage, and not in any other cell line. Membrane enriched extracts (50 µg lysate) of THP-1 (Lane 1), THP-1 differentiated to macrophage (Lane 2), SH-SY5Y (Lane 3), Raji (Lane 4) and HT-29 (Lane 5) were electrophoresed using Novex™ 16% Tricine Protein Gel (Product... View More
Product Details
PA5-28803
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 50 and 113 of Human DAP12
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2546279
Product Specific Information
Recommended positive controls: DAP12 tansfected 293T cell.
Predicted reactivity: Dog (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells. DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction. Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice, as well as presenile dementia and bone cysts in humans.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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