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Invitrogen
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Immunogen sequence: MEDAKVYVAK VDCTAHSDVC SAQGVRGYPT LKLFKPGQEA VKYQGPRDFQ TLENWMLQTL NEEPVTPEPE VEPPSAPELK QGLYELSASN FELHVAQGDH FIKFFAPWCG HCKALAPTWE QLALGLEHSE TVKIGKVDCT QHYELCSGNQ VRGYPTLLWF RDGKKVDQYK GKRDLESLRE YVESQLQRTE TGATETVTPS EAPVLAAEPE ADKGTVLALT ENNFDDTIAE GITFIKFYAP WCGHCKTLAP TWEELSKKEF PGLAGVKIAE VDCTAERNIC SKYSVRGYPT LLLFRGGKKV SEHSGGRDLD SLHRFVLSQA KDEL; Positive Samples: HepG2, HeLa, NCI-H460, SKOV3, Mouse liver; Cellular Location: Endoplasmic reticulum lumen
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
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