Invitrogen

TRPC1 Polyclonal Antibody

TRPC1 Antibody in Immunohistochemistry (Frozen) (IHC (F))

FIGURE: 1 / 5

TRPC1 Antibody (PA5-77303) in IHC (F)

Immunohistochemistry analysis of TRPC1 in frozen mouse cerebellum. A) Samples were probed with TRPC1 polyclonal antibody (Product # PA5-77303) and incubated with parvalbumin. B) Stains of brain section. C) Confocal merged image.

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TRPC1 Antibody — QLYDKGYTSKEQKDC, corresponding to amino acid residues 557-571 of human TRPC1

Product Details

PA5-77303

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent

Immunocytochemistry (ICC/IF)

1:200

Immunoprecipitation (IP)

Assay-Dependent

View 1 publication 1 publication

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide QLYDKGYTSKEQKDC, corresponding to amino acid residues 557-571 of human TRPC1

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

AB_2736729

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.

Reconstitute using 50 uL double distilled water.

Target Information

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Interacts with ITPR3. Appears to be ubiquitous.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.

The Journal of biological chemistry

Nieto-Felipe J,Sanchez-Collado J,Jardin I,Salido GM,Lopez JJ,Rosado JA

Published figure using TRPC1 polyclonal antibody (Product # PA5-77303) in Western Blot

Wed Feb 01 00:00:00 UTC 2023

The store-operated Ca²⁺ channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.

The Journal of biological chemistry

Nieto-Felipe J,Sanchez-Collado J,Jardin I,Salido GM,Lopez JJ,Rosado JA

Published figure using TRPC1 polyclonal antibody (Product # PA5-77303) in Western Blot

Wed Feb 01 00:00:00 UTC 2023

Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.

Cellular and molecular life sciences : CMLS

Sanchez-Collado J,Lopez JJ,Jardin I,Berna-Erro A,Camello PJ,Cantonero C,Smani T,Salido GM,Rosado JA

PA5-77303 was used in Western Blot to the role of Orai1α and Orai1β (canonical pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel) variants in the activation of TRPC1 in HeLa cells.

Thu Jan 06 00:00:00 UTC 2022

Furin Prodomain ppFurin Enhances Ca²⁺ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells.

Cancers

López JJ,Siegfried G,Cantonero C,Soulet F,Descarpentrie J,Smani T,Badiola I,Pernot S,Evrard S,Rosado JA,Khatib AM

Published figure using TRPC1 polyclonal antibody (Product # PA5-77303) in Western Blot

Thu Apr 01 00:00:00 UTC 2021

Performance Guarantee

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TRPC1 Polyclonal Antibody

TRPC1 Antibody (PA5-77303) in IHC (F)

Product Details

PA5-77303

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Performance Guarantee

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