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Invitrogen
TMEM38A Polyclonal Antibody
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FIGURE: 1 / 4
TMEM38A Antibody (PA5-77754) in ICC/IF
Immunocytochemistry analysis of TMEM38A in paraformaldehyde-fixed and permeabilized mouse muscle myoblast cell line. A) Samples were probed with TMEM38A polyclonal antibody (Product # PA5-77754) at a dilution of 1:200, and incubated with goat-anti-rabbit-AlexaFluor-594 and DAPI. B) Nuclei stained image. C) Merged images of Panels A and B.
Product Details
PA5-77754
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat
Conjugate
Form
Lyophilized
Concentration
0.9 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736709
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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