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PA5-32212 targets TET1 in WB, ICC and IF applications and shows reactivity with mouse samples.
The PA5-32212 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 218 of Human Tet1.
Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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