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Invitrogen
TC2N Polyclonal Antibody
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Product Details
PA5-26433
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human TAC2N
Conjugate
Form
Liquid
Concentration
Lot-specific
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2543933
Target Information
The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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