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Invitrogen
Sir2.1 Polyclonal Antibody
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Product Details
PA1-16933
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full-length recombinant Sir2.1 protein.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_795769
Target Information
Sir2 (silent information regulator 2) protein plays a crucial role in regulating the life span of C. elegans by means of caloric restricion. Overexpression of the protein can extend the life span, and is, thus, a regulator of longevity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: NAD-dependent protein deacetylase sir-2.1; Protein sir-2.1; Regulatory protein SIR2 homolog 1
Gene Aliases: R11A8.4; sir-2.1
UniProt ID: (C. elegans) Q21921
Entrez Gene ID: (C. elegans) 177924
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
p53 binding
transcription corepressor activity
protein binding
protein C-terminus binding
hydrolase activity
NAD-dependent histone deacetylase activity
deacetylase activity
protein domain specific binding
nuclear hormone receptor binding
bHLH transcription factor binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
mitogen-activated protein kinase binding
NAD+ binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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