Invitrogen

Sigma-1 Receptor Polyclonal Antibody

Sigma-1 Receptor Antibody in Western Blot (WB)

FIGURE: 1 / 2

Sigma-1 Receptor Antibody (PA5-77467) in WB

Western blot analysis of rat liver (lanes 1 and 3) and mouse liver (lanes 2 and 4) membranes with Sigma-1 Receptor polyclonal antibody (Product # PA5-77467) using a dilution of 1:200.

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Product Details

PA5-77467

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Product Specifications

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide (C)SRGHSGRYWAEISD, corresponding to amino acid residues 113-126 of human Sigma-1 Receptor

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

AB_2736596

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.

Target Information

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain.

Gene therapy

Shin SM,Wang F,Qiu C,Itson-Zoske B,Hogan QH,Yu H

PA5-77467 was used in Western Blot, Immunohistochemistry (Paraffin) to show that further understanding the role of PSN-σ1R in pain pathology may open routes to exploit this system for DRG-targeted pain therapy.

Tue Feb 01 00:00:00 UTC 2022