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Immunogen sequence: DRDSNHTSEG NGDSLLADED TDFEDSLNRN VKKRAAKRPP KTTPVAKHPK KGSRVVHRHS RKQSEPPAND LFNAV
Highest antigen sequence identity to the following orthologs: Mouse - 58%, Rat - 61%.
STAG3 is a meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
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