Proteintech

SP110 Polyclonal Antibody

FIGURE: 1 / 14

SP110 Antibody (11502-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 11502-1-AP) SP110 antibody at dilution of 1:6,000 incubated at room temperature for 1.5 hours.

SP110 Antibody in Immunoprecipitation (IP)

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Product Details

11502-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

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Immunocytochemistry (ICC/IF)

Assay-dependent

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Flow Cytometry (Flow)

Assay-dependent

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Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SP110 Fusion Protein Ag2042 (1-350 aa encoded by BC019059)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MFTMTRAME EALFQHFMHQ KLGIAYAIHK PFPFFEGLLD NSIITKRMYM ESLEACRNLI PVSRVVHNIL TQLERTFNLS LLVTLFSQIN LREYPNLVTI YRSFKRVGAS YERQSRDTPI LLEAPTGLAE GSSLHTPLAL PPPQPPQPSC SPCAPRVSEP GTSSQQSDEI LSESPSPSDP VLPLPALIQE GRSTSVTNDK LTSKMNAEED SEEMPSLLTS TVQVASDNLI PQIRDKEDPQ EMPHSPLGSM PEIRDNSPEP NDPEEPQEVS STPSDKKGKK RKRCIWSTPK RRHKKKSLPR ALSRHGIQKK LKRVDQVPQK KDDSTCNSTV ETRAQKARTE CARKSRSEEI I (1-350 aa encoded by BC019059)

Target Information

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.