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Invitrogen
SOCS3 Polyclonal Antibody
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FIGURE: 1 / 2
SOCS3 Antibody (PA5-29628) in WB
Western Blot using SOCS3 Polyclonal Antibody (Product # PA5-29628). Untreated (–) and treated (+) Raw264.7 whole cell extracts (50 µg) were separated by 12% SDS-PAGE, and the membrane was blotted with SOCS3 Polyclonal Antibody (Product # PA5-29628) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody, and the signal was developed with Trident ECL plus-Enhanced.
Product Details
PA5-29628
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 225 of Human SOCS3
Conjugate
Form
Liquid
Concentration
0.89 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2547103
Product Specific Information
PA5-29628 targets SOCS3 in WB applications and shows reactivity with Human samples.
The PA5-29628 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 225 of Human SOCS3.
Target Information
Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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