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Abnova
SHOX2 Polyclonal Antibody, MaxPab™
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Product Details
H00006474-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SHOX2 (AAH08829.1, 1 a.a. approximately 355 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEELTAFVSK SFDQKVKEKK EAITYREVLE SGPLRGAKEP TGCTEAGRDD RSSPAVRAAG GGGGGGGGGG GGGGGGGVGG GGAGGGAGGG RSPVRELDMG AAERSREPGS PRLTEGRRKP TKAEVQATLL LPGEAFRFLV SPELKDRKED AKGMEDEGQT KIKQRRSRTN FTLEQLNELE RLFDETHYPD AFMREELSQR LGLSEARVQV WFQNRRAKCR KQENQLHKGV LIGAASQFEA CRVAPYVNVG ALRMPFQQDS HCNVTPLSFQ VQAQLQLDSA VAHAHHHLHP HLAAHAPYMM FPAPPFGLPL ATLAADSASA ASVVAAAAAA KTTSKNSSIA DLRLKAKKHA AALGL
Target Information
SHOX2 is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is a member of the homeo box family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeo box genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeo box genes. SHOX is a pseudoautosomal homeo box gene that is thought to be responsible for idiopathic short stature and implicated to play a role in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein Og12X; OGI2X; Paired-related homeobox protein SHOT; Short stature homeobox protein 2; SHOX homologous gene on chromosome 3
Gene Aliases: OG12; OG12X; SHOT; SHOX2
UniProt ID: (Human) O60902
Entrez Gene ID: (Human) 6474
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
positive regulation of mesenchymal cell proliferation
chondrocyte development
heart valve development
cardiac atrium morphogenesis
nervous system development
heart development
regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
embryonic digestive tract morphogenesis
positive regulation of skeletal muscle fiber development
positive regulation of axonogenesis
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
muscle tissue morphogenesis
regulation of branching morphogenesis of a nerve
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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