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PA1-27075 detects Thyroxine Binding Globulin from human samples. PA1-27075 will not react with related serum proteins.
PA1-27075 has been successfully used in radioimmune assay procedures.
The PA1-27075 immunogen is Thyroxine Binding Globulin purified from human serum (> 95% pure by SDS-PAGE).
There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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