Invitrogen

SDPR Polyclonal Antibody

SDPR Antibody in Immunohistochemistry (IHC)

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SDPR Antibody (PA5-58736) in IHC

Immunohistochemical staining of SDPR in human spleen and skin tissues using SDPR Polyclonal Antibody (Product # PA5-58736). Corresponding SDPR RNA-seq data are presented for the same tissues.

Product Image Gallery

SDPR Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of SDPR demonstrates antibody specificity. Immunohistochemical analysis of SDPR using anti-SDPR Polyclonal Antibody (Product # PA5-58736), shows significant staining of SDPR in human spleen and shows minimal or weak staining in human skin tissues. The relative expression levels of SDPR within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-58736

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:2,500-1:5,000

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SDPR

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_2647057

Product Specific Information

Immunogen sequence: VSVERREKIK KSLTSNHQKI SSGKSSPFKV SPLTFGRKKV REGESHAENE TKSEDLPSSE QMPNDQEEES FAEGHSEASL ASALVEGEIA EEAAEKATSR GSNSGMDSNI DLTIVEDEEE ESVALEQAQK VRYE

Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 73%.

Target Information

The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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