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Invitrogen
SCN4B (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
SCN4B (extracellular) Antibody (PA5-77742) in IHC
Immunohistochemistry analysis of SCN4B (extracellular) in adult rat dorsal root ganglion. A) Samples were probed with SCN4B (extracellular) polyclonal antibody (Product # PA5-77742) and incubated with DAPI. B) Nuclei stained image. C) Merged image of Panels A and B.
Product Details
PA5-77742
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85-98 of rat NaV beta4
Conjugate
Form
Lyophilized
Concentration
0.85 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736571
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitute using 50 uL deionized water.
Target Information
The SCN4B protein modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. The protein has been found to be expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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