Invitrogen

S100A4 Polyclonal Antibody

S100A4 Antibody in Immunohistochemistry (IHC)

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S100A4 Antibody (PA5-16586) in IHC

Formalin-fixed, paraffin-embedded human tonsil stained with S100A4 using peroxidase-conjugate and AEC chromogen. Note membrane staining of lymphocytes.

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Product Details

PA5-16586

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200

Product Specifications

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Purified recombinant human S100 A4 monomer expressed in E. coli

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

4°C

Shipping conditions

Wet ice

AB_10977371

Product Specific Information

PA5-16586 targets S100 A4 in IHC (P) applications and shows reactivity with Bovine, Canine, Equine, Feline, Human, mouse, and Rat samples.

The PA5-16586 immunogen is purified recombinant human S100 A4 monomer expressed in E. coli.

Target Information

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Plasma CD147 reflects histological features in patients with lupus nephritis.

Lupus

Maeda-Hori M,Kosugi T,Kojima H,Sato W,Inaba S,Maeda K,Nagaya H,Sato Y,Ishimoto T,Ozaki T,Tsuboi N,Muro Y,Yuzawa Y,Imai E,Johnson RJ,Matsuo S,Kadomatsu K,Maruyama S

PA5-16586 was used in immunohistochemistry to study the value of plasma CD147 levels as a marker of lupus nephritis disease status

Tue Apr 01 00:00:00 UTC 2014

Expression of fibroblast specific protein-1 in pleural tuberculosis and its clinical biological significance.

World journal of surgical oncology

Sun ZM,Li FY,Wang L,Wang HY,Deng Y,Yao Y

PA5-16586 was used in immunohistochemistry to study the clinical significance of the immunohistochemical expression of S100A4 in patients with pleural tuberculosis

Tue May 20 00:00:00 UTC 2014

S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-κB-dependent MMP-9 signal.

European review for medical and pharmacological sciences

Zhang J,Zhang DL,Jiao XL,Dong Q

PA5-16586 was used in immunohistochemistry to study the role of NFkB-dependent MMP-9 expression in the mechanism by which S100A4 modulates HepG2 migration and invasion

Sun Sep 01 00:00:00 UTC 2013

Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy.

Laboratory investigation; a journal of technical methods and pathology

Du X,Shimizu A,Masuda Y,Kuwahara N,Arai T,Kataoka M,Uchiyama M,Kaneko T,Akimoto T,Iino Y,Fukuda Y

PA5-16586 was used in immunohistochemistry to study the role of MMP2 in the pathogenesis of murine renal interstitial fibrosis

Wed Aug 01 00:00:00 UTC 2012

Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front.

International journal of colorectal disease

Kho PS,Jankova L,Fung CL,Chan C,Clarke C,Lin BP,Robertson G,Molloy M,Chapuis PH,Bokey EL,Dent OF,Clarke S

PA5-16586 was used in immunohistochemistry to study the prognostic value of S100A4 expression in stage C colon cancer patients

Thu Nov 01 00:00:00 UTC 2012

FoxQ1 overexpression influences poor prognosis in non-small cell lung cancer, associates with the phenomenon of EMT.

PloS one

Feng J,Zhang X,Zhu H,Wang X,Ni S,Huang J

PA5-16586 was used in immunohistochemistry to study the prognostic value of FoxQ1 expression in non-small cell lung cancer

Fri Jan 04 00:00:00 UTC 2013

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