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Abnova
RNF157 Monoclonal Antibody (6B3)
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Product Details
H00114804-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
6B3
Immunogen
RNF157 (NP_443148, 556 a.a. approximately 655 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PASRAPSEEG EGLPAESPDS NFAGLPAGEQ DAEGNDVIEE EDGSPTQEGQ RTCAFLGMEC DNNNDFDIAS VKALDNKLCS EVCLPGAWQA DDNAVSRNAQ
Target Information
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin ligase RNF157; RING finger protein 157; RING-type E3 ubiquitin transferase RNF157
Gene Aliases: KIAA1917; RNF157
UniProt ID: (Human) Q96PX1
Entrez Gene ID: (Human) 114804
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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