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Invitrogen
RASGRP1 Polyclonal Antibody
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Product Details
PA5-65431
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human RASGRP1
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2662280
Product Specific Information
Immunogen sequence: RKTAQDTLYVL PSPTSPCPSP VLVRKRAFVK WENKDSLIKS KEELRHLRLP TYQELEQEIN TLKADNDALK IQLKYAQKKI ESLQLEKSNH VLAQMEQGD
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 82%.
Target Information
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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