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Invitrogen
Phospho-PYK2 (Tyr579, Tyr580) Polyclonal Antibody
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Product Details
PA1-26674
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosines 579 and 580. The sequence is conserved in human and rat.
Conjugate
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2300490
Product Specific Information
PA1-26674 detects PYK2 (phospho Y579 + Y580) from human and rat samples.
PA1-26674 has been successfully used in Western blot procedures. Suggested positive control is vandate treated CEF cells expressing PYK 2 and plated on fibronectin.
The PA1-26674 immunogen is a synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosines 579 and 580. The sequence is conserved in human and rat.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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