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Invitrogen
Phospho-PYK2 (Tyr579) Polyclonal Antibody
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Product Details
PA1-26673
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosine 579. The sequence is conserved in mouse and rat.
Conjugate
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_795272
Product Specific Information
PA1-26673 detects PYK2 (phospho Y579) from human samples. PA1-26673 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.
PA1-26673 has been successfully used in Western blot procedures.
The PA1-26673 immunogen is a synthetic phosphopeptide corresponding to a portion of human Pyk 2 containing tyrosine 579. The sequence is conserved in mouse and rat.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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