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Invitrogen
Phospho-PKR (Thr451) Polyclonal Antibody
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Product Details
PA1-26677
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of PKR that contains threonine451. The sequence was aligned to human.
Conjugate
Form
Liquid
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_795195
Product Specific Information
PA1-26677 detects PKR (phospho T451) from human samples. PA1-26677 is expected to cross react with mouse (73% conserved).
PA1-26677 has been successfully used in Western blot procedures.
The PA1-26677 immunogen is a synthetic phosphopeptide corresponding to a portion of PKR that contains threonine451. The sequence was aligned to human.
Target Information
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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