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PA1-25988 detects PKC mu (phospho S742) from human and mouse samples.
PA1-25988 has been successfully used in Western blot procedures.
The PA1-25988 immunogen is a synthetic phosphopeptide corresponding to a portion of human PKC mu containing serine 742. The sequence is conserved in mouse.
The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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