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Invitrogen
Phospho-MEK1/MEK2 (Ser221) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-MEK1/MEK2 (Ser221) Antibody (PA1-26646) in IHC
Immunofluorescent analysis of Phospho-MEK1 + MEK2 pSer221 in mouse embryonic fibroblasts using a Phospho-MEK1 + MEK2 pSer221 polyclonal antibody (Product # PA1-26646) showing cell division. Blue represents chromosomes in anaphase of mitotic cell division. Green shows mitotic spindle expressing phosphorylated MEK1/2.
Product Details
PA1-26646
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human MEK 1 + 2 containing serine 222. The sequence is conserved in many species including mous
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_794842
Product Specific Information
PA1-26646 detects MEK1 + MEK2 (phospho S222) from human, mouse, and rat samples. PA1-26646 is expected to cross react with chicken, chimpanzee, and Xenopus laevis due to sequence homology.
PA1-26646 has been successfully used in Western blot procedures.
The PA1-26646 immunogen is a synthetic phosphopeptide corresponding to a portion of human MEK 1 + 2 containing serine 222. The sequence is conserved in many species including mouse, rat, chimp, chicken, frog, and others.
Target Information
MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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