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Invitrogen
Phospho-JAK1 (Tyr1022, Tyr1023) Polyclonal Antibody
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Product Details
OPA1-03051A
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic JAK1 peptide that is phosphorylated at tyrosines 1022 and 1023.
Conjugate
Form
Liquid
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
OPA1-03051A detects phospho-JAK1 (pTyr 1022/1023) in human and mouse samples. This product has been shown to not react with rat JAK1.
OPA1-03051A has been successfully used in Western blotting. By Western blot, this antibody detects an ~130 kDa protein representing JAK1 phosphorylated at tyrosines 1022 and 1023.
The OPA1-03051A immunogen is a synthetic peptide derived from a region of human JAK1 that contains tyrosines 1022 and 1023. This sequence is conserved in mouse and pig.
Target Information
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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