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PA1-26725 detects Insulin Receptor / IGF1R (phospho Y1158 + Y1162 + Y1163) from human and mouse samples. PA1-26725 is expected to cross react with rat (100% conserved) due to sequence homology.
PA1-26725 has been successfully used in Western blot procedures.
The PA1-26725 immunogen is a synthetic phosphopeptide corresponding to a portion of IR/IGF1R containing tyrosines 1158, 1162, and 1163 of human insulin receptor (tyrosines 1131, 1135 and 1136 in IGF1R).
IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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