Invitrogen

Phospho-GluR1 (Ser845) Polyclonal Antibody

Product Details

PA1-12749

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 3 publications 3 publications

Product Specifications

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Sythetic peptide corresponding to amino acid residues surrounding phospho-Ser845 of rat GluR1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

AB_1086368

Product Specific Information

This antibody recognizes a ~100kD band corresponding to GluR1 phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling can blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide, and is completely eliminated by treatment with lambda-phosphatase.

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

Neuron

Li S,Jin M,Zhang D,Yang T,Koeglsperger T,Fu H,Selkoe DJ

PA1-12749 was used in western blot to study the role of beta2-adrenergic receptor activation in the mechanism by which environmental enrichment inhibits the deleterious effects of Abeta oligomers on hippocampal function

Wed Mar 06 00:00:00 UTC 2013

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Hippocampus

Giralt A,Saavedra A,Carretón O,Arumí H,Tyebji S,Alberch J,Pérez-Navarro E

PA1-12749 was used in western blot to study the role of increased phosphorylation of GluA1 and CREB in the mechanism by which pharmacological inhibition of PDE10 improves memory in a murine model of Huntington's disease

Thu Aug 01 00:00:00 UTC 2013

Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice.

Neuropharmacology

Chen H,Manev H

PA1-12749 was used in western blot to study the role of 5-lipoxygenase in the effect of antibiotic minocycline on cocaine sensitization

Wed Jun 01 00:00:00 UTC 2011

Performance Guarantee

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