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Invitrogen
Phospho-EIF2S1 (Ser52) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-EIF2S1 (Ser52) Antibody (PA1-26686) in IHC
Immunofluorescent analysis of Phospho-EIF2A pSer52 using a Phospho-EIF2A pSer52 polyclonal antibody (Product # PA1-26686). Left: rat brain (mediodorsal neocortex) sections following traumatic axonal injury (TAI) (24 h). Control (prior to injury induction) shows low basal levels of EIF2 alpha. Right: Image shows double labeling of APP (red) and EIF2 alpha (green) in neurons subjected to traumatic axonal inju... View More
Product Details
PA1-26686
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human eIF-2 alpha containing serine 52. This portion is conserved among many species including rat, pig, cow, fruit fly and yeast.
Conjugate
Form
Liquid
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2096471
Product Specific Information
PA1-26686 detects eIF2A (phospho S52) from human and mouse samples. PA1-26686 is expected to cross react with a wide range of other species due to sequence homology.
PA1-26686 has been successfully used in Western blot procedures.
The PA1-26686 immunogen is a synthetic phosphopeptide corresponding to a portion of human eIF-2 alpha containing serine 52. This portion is conserved among many species including rat, pig, cow, fruit fly, and yeast.
Target Information
EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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