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Invitrogen
Phospho-CaMKII alpha (Thr286) Polyclonal Antibody
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Product Details
PA1-26727
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to a portion of human CaM Kinase II alpha containing threonine 286.
Conjugate
Form
Liquid
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_779494
Product Specific Information
PA1-26727 detects CaMKII alpha (phospho T286) from human samples. PA1-26727 is expected to cross react with mouse (100% conserved), and rat (100% conserved) due to sequence homology.
PA1-26727 has been successfully used in Western blot procedures.
The PA1-26727 immunogen is a synthetic phosphopeptide corresponding to a portion of human CaM Kinase II alpha containing threonine 286.
Store at 4°C for short term storage. For long term storage store at -20°C or below. Avoid Freeze/Thaw Cycles.
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates a number of cellular functions including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostatsis. Autophosphorylation of threonine 286 in the presence of Ca2+ and calmodulin activates CAMK2A with the ability to switch from calmodulin-dependent to a calmodulin independent activity. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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