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Invitrogen
Pellino 2 Polyclonal Antibody
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Product Details
PA1-20825
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide: GHRSDTEANEREC, corresponding to amino acids 323-335 of Human Pellino 2.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2161351
Product Specific Information
PA1-20825 detects Pellino 2 in Human and Mouse samples.
PA1-20825 has been successfully used in Western Blot procedures. Detects a band at approximatelyl 46 kDa. Positive control of human spleen and raw cells suggested.
PA1-20825 immunogen corresponds to Synthetic peptide: GHRSDTEANEREC, corresponding to amino acids 323-335 of Human Pellino 2.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
Target Information
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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