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Invitrogen
PTTG2 Polyclonal Antibody
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FIGURE: 1 / 3
PTTG2 Antibody (PA5-30881) in ICC/IF
PTTG2 Polyclonal Antibody detects PTTG2 protein at nucleus by immunofluorescent analysis. Sample: NT2D1 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PTTG2 protein stained by PTTG2 Polyclonal Antibody (Product # PA5-30881) diluted at 1:1,000. Blue: Hoechst 33342 staining.
Product Details
PA5-30881
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human PTTG2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548355
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PTTG2 (Pituitary Tumor-Transforming Gene 2) gene is part of a family of securin proteins involved in regulating sister chromatid separation during cell division. Located on chromosome 8q13, PTTG2 acts as a securin, inhibiting separase to prevent premature separation of sister chromatids until proper chromosome alignment is achieved during mitosis. PTTG2 is expressed in various tissues and has been implicated in tumorigenesis due to its role in cell cycle regulation and its potential to induce genetic instability when dysregulated. Overexpression of PTTG2 has been observed in several cancers, including pituitary adenomas, and is associated with increased cell proliferation, invasion, and metastasis. Due to its involvement in mitotic regulation and tumor development, PTTG2 is considered a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Understanding the molecular mechanisms regulated by PTTG2 could aid in the development of novel cancer treatments.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pituitary tumor-transforming gene 2 protein; Securin-2
Gene Aliases: PTTG2
UniProt ID: (Human) Q9NZH5
Entrez Gene ID: (Human) 10744
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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