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Abnova
PTTG2 Polyclonal Antibody, MaxPab™
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Product Details
H00010744-D01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTTG2 (NP_006598.1, 1 a.a. approximately 191 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTPRFGKTY DAPSALPKAT RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLFA VSFKHSVDPG C
Target Information
The PTTG2 (Pituitary Tumor-Transforming Gene 2) gene is part of a family of securin proteins involved in regulating sister chromatid separation during cell division. Located on chromosome 8q13, PTTG2 acts as a securin, inhibiting separase to prevent premature separation of sister chromatids until proper chromosome alignment is achieved during mitosis. PTTG2 is expressed in various tissues and has been implicated in tumorigenesis due to its role in cell cycle regulation and its potential to induce genetic instability when dysregulated. Overexpression of PTTG2 has been observed in several cancers, including pituitary adenomas, and is associated with increased cell proliferation, invasion, and metastasis. Due to its involvement in mitotic regulation and tumor development, PTTG2 is considered a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Understanding the molecular mechanisms regulated by PTTG2 could aid in the development of novel cancer treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pituitary tumor-transforming gene 2 protein; Securin-2
Gene Aliases: PTTG2
UniProt ID: (Human) Q9NZH5
Entrez Gene ID: (Human) 10744
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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