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Invitrogen
PTPRG Polyclonal Antibody
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FIGURE: 1 / 1
PTPRG Antibody (PA5-89705) in WB
Western blot analysis of PTPRG in extracts of various cell lines. Samples were incubated with PTPRG Polyclonal antibody (Product # PA5-89705) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-89705
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 250-450 of human PTPRG (NP_0028323)
Conjugate
Form
Liquid
Concentration
1.53 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805736
Product Specific Information
Immunogen sequence: YRYTGSLTTP PCSEIVEWIV FRRPVPISYH QLEAFYSIFT TEQQDHVKSV EYLRNNFRPQ QRLHDRVVSK SAVRDSWNHD MTDFLENPLG TEASKVCSSP PIHMKVQPLN QTALQVSWSQ PETIYHPPIM NYMISYSWTK NEDEKEKTFT KDSDKDLKAT ISHVSPDSLY LFRVQAVCRN DMRSDFSQTM LFQANTTRIF Q; Positive Samples: A-549, 293T, Mouse kidney, Mouse heart, Mouse liver, Rat spleen; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
RPTP gamma, also known as Receptor-type tyrosine-protein phosphatase gamma, R-PTP-gamma or PTPRG is a protein tyrosine phosphatase (PTP) is a candidate tumor suppressor gene since it is located on human chromosome 3p14.2-p21, a region frequently deleted in certain types of renal and lung carcinomas. In situ hybridization analysis reveals that RPTP gamma mRNA is expressed in specific regions of the brain and that the localization of RPTP gamma changes during brain development. RPTP gamma is composed of a putative extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic tyrosine phosphatase domains. The extracellular domain contains a stretch of 266 amino acids with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), indicating that RPTP gamma and RPTP beta (HPTP zeta) represent a subfamily of receptor tyrosine phosphatases. RPTP gamma may have a function other than catalysis of hydration of metabolic CO2.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H_RG317H01.1; protein tyrosine phosphatase gamma; protein tyrosine phosphatase, receptor type, G; protein tyrosine phosphatase, receptor type, gamma polypeptide; Protein-tyrosine phosphatase gamma; Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma); R-PTP-gamma; receptor type protein tyrosine phosphatase gamma; receptor tyrosine phosphatase gamma; receptor-like protein tyrosine phosphatase gamma; receptor-type protein phosphatase gamma; Receptor-type tyrosine-protein phosphatase gamma; RPTP gamma A; RPTP gamma B; RPTP gamma C; RPTP gamma S
Gene Aliases: 5430405N12Rik; AW046354; AW549872; HPTPG; PTPG; PTPRG; R-PTP-GAMMA; RPTPG; RPTPgamma
UniProt ID: (Human) P23470, (Mouse) Q05909
Entrez Gene ID: (Human) 5793, (Mouse) 19270, (Rat) 171357
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of epithelial cell migration
peptidyl-tyrosine dephosphorylation
regulation of homophilic cell adhesion
protein dephosphorylation
negative regulation of neuron projection development
dephosphorylation
toxin transport
brain development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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