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Invitrogen
PTGER2 (extracellular) Polyclonal Antibody
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PTGER2 (extracellular) Antibody (PA5-77693) in IHC (F)
Immunohistochemistry analysis of PTGER2 (extracellular) in perfusion-fixed, frozen rat brain. Samples were probed with PTGER2 (extracellular) polyclonal antibody (Product # PA5-77693) using a dilution of 1:100, and incubated with DAPI.
Product Details
PA5-77693
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)DETSSRKEKWDLR, corresponding to amino acid residues 287-299 of rat prostanoid EP2 receptor
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2736477
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
Prostaglandins are produced by the metabolism of arachidonic acid. Prostaglandin E2 is one of the five physiologically significant prostanoids known. Its wide spectrum of physiologic and pharmacologic effects in various tissues is mediated through binding to the Prostaglandin E2 receptors (EP1, EP2, EP3 & EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation. PGE-2 signals through a family of G-protein coupled receptors known as EP receptors. There are 4 subtypes of EP receptors, known as EP1, EP2, EP3 and EP4. EP2 receptors are 358 amino acid proteins with a short third intracellular loop. EP2 receptors stimulate adenylyl cyclase by their coupling to Gs and do not undergo PGE-2-induced internalization. The EP2 receptors is involved with the contration and relaxation of smooth muscle tissue. These receptors are mainly localized in lung and placental tissues and in smooth muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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