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Invitrogen
PSMC3IP Polyclonal Antibody
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PSMC3IP Antibody (PA5-60712)
Relative expression in different tissues in IHC: Detection of differential expression levels of PSMC3IP demonstrates antibody specificity. Immunohistochemical analysis of PSMC3IP using anti-PSMC3IP Polyclonal Antibody (Product # PA5-60712), shows significant staining of PSMC3IP in human testis and shows minimal or weak staining in human liver tissues. The relative expression levels of PSMC3IP within each t... View More
Product Details
PA5-60712
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PSMC3IP
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646063
Product Specific Information
Immunogen sequence: PEEKEQVYRE RQKYCKEWRK RKRMATELSD AILEGYPKSK KQFFEEVGIE TDEDYNVTLP D
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 93%.
Target Information
PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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