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Invitrogen
PSEN2 Polyclonal Antibody
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Product Details
PA1-1753
Product Specifications
Host/Isotype
Chicken
/ IgY
Class
Polyclonal
Type
Antibody
Immunogen
Mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2284396
Product Specific Information
PA1-1753 detects presenilin 2 protein (PS2) from human, rat and mouse samples.
PA1-1753 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~66 kDa protein representing PS2
The PA1-1753 immunogen is a mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.
Target Information
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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