Product References
Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags.
Life science alliance
Morón-Oset J,Fischer LK,Carcolé M,Giblin A,Zhang P,Isaacs AM,Grönke S,Partridge L
Fri Sep 01 00:00:00 UTC 2023
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Cell
Hung ST,Linares GR,Chang WH,Eoh Y,Krishnan G,Mendonca S,Hong S,Shi Y,Santana M,Kueth C,Macklin-Isquierdo S,Perry S,Duhaime S,Maios C,Chang J,Perez J,Couto A,Lai J,Li Y,Alworth SV,Hendricks E,Wang Y,Zlokovic BV,Dickman DK,Parker JA,Zarnescu DC,Gao FB,Ichida JK
Thu Feb 16 00:00:00 UTC 2023
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.
Cell stem cell
Linares GR,Li Y,Chang WH,Rubin-Sigler J,Mendonca S,Hong S,Eoh Y,Guo W,Huang YH,Chang J,Tu S,Dorjsuren N,Santana M,Hung ST,Yu J,Perez J,Chickering M,Cheng TY,Huang CC,Lee SJ,Deng HJ,Bach KT,Gray K,Subramanyam V,Rosenfeld J,Alworth SV,Goodarzi H,Ichida JK
Thu Feb 02 00:00:00 UTC 2023
New regulators of the tetracycline-inducible gene expression system identified by chemical and genetic screens.
FEBS open bio
Colicchia V,Häggblad M,Sirozh O,Porebski B,Balan M,Li X,Lidemalm L,Carreras-Puigvert J,Hühn D,Fernandez-Capetillo O
Sat Oct 01 00:00:00 UTC 2022
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Frontiers in cellular neuroscience
Bauer CS,Webster CP,Shaw AC,Kok JR,Castelli LM,Lin YH,Smith EF,Illanes-Álvarez F,Higginbottom A,Shaw PJ,Azzouz M,Ferraiuolo L,Hautbergue GM,Grierson AJ,De Vos KJ
Tue Sep 10 00:00:00 UTC 2024
Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins.
Science translational medicine
Gao J,Mewborne QT,Girdhar A,Sheth U,Coyne AN,Punathil R,Kang BG,Dasovich M,Veire A,DeJesus Hernandez M,Liu S,Shi Z,Dafinca R,Fouquerel E,Talbot K,Kam TI,Zhang YJ,Dickson D,Petrucelli L,van Blitterswijk M,Guo L,Dawson TM,Dawson VL,Leung AKL,Lloyd TE,Gendron TF,Rothstein JD,Zhang K
Wed Sep 14 00:00:00 UTC 2022
Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model.
eLife
Frottin F,Pérez-Berlanga M,Hartl FU,Hipp MS
Wed Jun 23 00:00:00 UTC 2021
NDST3 deacetylates α-tubulin and suppresses V-ATPase assembly and lysosomal acidification.
The EMBO journal
Tang Q,Liu M,Liu Y,Hwang RD,Zhang T,Wang J
Fri Oct 01 00:00:00 UTC 2021
SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72.
Journal of cell science
Malnar M,Rogelj B
Fri Feb 19 00:00:00 UTC 2021
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Biochimica et biophysica acta. Molecular cell research
Leskelä S,Huber N,Hoffmann D,Rostalski H,Remes AM,Takalo M,Hiltunen M,Haapasalo A
Tue Jun 01 00:00:00 UTC 2021
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Biochimica et biophysica acta. Molecular cell research
Leskelä S,Huber N,Hoffmann D,Rostalski H,Remes AM,Takalo M,Hiltunen M,Haapasalo A
Tue Jun 01 00:00:00 UTC 2021
Dipeptide repeat proteins inhibit homology-directed DNA double strand break repair in C9ORF72 ALS/FTD.
Molecular neurodegeneration
Andrade NS,Ramic M,Esanov R,Liu W,Rybin MJ,Gaidosh G,Abdallah A,Del'Olio S,Huff TC,Chee NT,Anatha S,Gendron TF,Wahlestedt C,Zhang Y,Benatar M,Mueller C,Zeier Z
Mon Feb 24 00:00:00 UTC 2020
The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.
The EMBO journal
Kawabe Y,Mori K,Yamashita T,Gotoh S,Ikeda M
Thu Oct 01 00:00:00 UTC 2020
C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons.
Molecules and cells
Park JH,Chung CG,Seo J,Lee BH,Lee YS,Kweon JH,Lee SB
Wed Sep 30 00:00:00 UTC 2020
C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons.
Molecules and cells
Park JH,Chung CG,Seo J,Lee BH,Lee YS,Kweon JH,Lee SB
Wed Sep 30 00:00:00 UTC 2020
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD.
Cell reports
Li S,Wu Z,Li Y,Tantray I,De Stefani D,Mattarei A,Krishnan G,Gao FB,Vogel H,Lu B
Tue Aug 04 00:00:00 UTC 2020
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
JCI insight
Shi Y,Hung ST,Rocha G,Lin S,Linares GR,Staats KA,Seah C,Wang Y,Chickering M,Lai J,Sugawara T,Sagare AP,Zlokovic BV,Ichida JK
Tue Jul 16 00:00:00 UTC 2019
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
JCI insight
Shi Y,Hung ST,Rocha G,Lin S,Linares GR,Staats KA,Seah C,Wang Y,Chickering M,Lai J,Sugawara T,Sagare AP,Zlokovic BV,Ichida JK
Tue Jul 16 00:00:00 UTC 2019
Motor dysfunction and neurodegeneration in a C9orf72 mouse line expressing poly-PR.
Nature communications
Hao Z,Liu L,Tao Z,Wang R,Ren H,Sun H,Lin Z,Zhang Z,Mu C,Zhou J,Wang G
Tue Jul 02 00:00:00 UTC 2019
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.
Nature neuroscience
Yamada SB,Gendron TF,Niccoli T,Genuth NR,Grosely R,Shi Y,Glaria I,Kramer NJ,Nakayama L,Fang S,Dinger TJI,Thoeng A,Rocha G,Barna M,Puglisi JD,Partridge L,Ichida JK,Isaacs AM,Petrucelli L,Gitler AD
Sun Sep 01 00:00:00 UTC 2019
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.
Neuropathology and applied neurobiology
Davidson Y,Robinson AC,Liu X,Wu D,Troakes C,Rollinson S,Masuda-Suzukake M,Suzuki G,Nonaka T,Shi J,Tian J,Hamdalla H,Ealing J,Richardson A,Jones M,Pickering-Brown S,Snowden JS,Hasegawa M,Mann DM
Fri Apr 01 00:00:00 UTC 2016
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.
Neuropathology and applied neurobiology
Davidson Y,Robinson AC,Liu X,Wu D,Troakes C,Rollinson S,Masuda-Suzukake M,Suzuki G,Nonaka T,Shi J,Tian J,Hamdalla H,Ealing J,Richardson A,Jones M,Pickering-Brown S,Snowden JS,Hasegawa M,Mann DM
Fri Apr 01 00:00:00 UTC 2016
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.
Neuropathology and applied neurobiology
Davidson Y,Robinson AC,Liu X,Wu D,Troakes C,Rollinson S,Masuda-Suzukake M,Suzuki G,Nonaka T,Shi J,Tian J,Hamdalla H,Ealing J,Richardson A,Jones M,Pickering-Brown S,Snowden JS,Hasegawa M,Mann DM
Fri Apr 01 00:00:00 UTC 2016
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins.
Neuropathology and applied neurobiology
Davidson Y,Robinson AC,Liu X,Wu D,Troakes C,Rollinson S,Masuda-Suzukake M,Suzuki G,Nonaka T,Shi J,Tian J,Hamdalla H,Ealing J,Richardson A,Jones M,Pickering-Brown S,Snowden JS,Hasegawa M,Mann DM
Fri Apr 01 00:00:00 UTC 2016
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Stem cells (Dayton, Ohio)
Dafinca R,Scaber J,Ababneh N,Lalic T,Weir G,Christian H,Vowles J,Douglas AG,Fletcher-Jones A,Browne C,Nakanishi M,Turner MR,Wade-Martins R,Cowley SA,Talbot K
Mon Aug 01 00:00:00 UTC 2016
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Stem cells (Dayton, Ohio)
Dafinca R,Scaber J,Ababneh N,Lalic T,Weir G,Christian H,Vowles J,Douglas AG,Fletcher-Jones A,Browne C,Nakanishi M,Turner MR,Wade-Martins R,Cowley SA,Talbot K
Mon Aug 01 00:00:00 UTC 2016
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
Human molecular genetics
Bennion Callister J,Ryan S,Sim J,Rollinson S,Pickering-Brown SM
Thu Dec 01 00:00:00 UTC 2016
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
Human molecular genetics
Bennion Callister J,Ryan S,Sim J,Rollinson S,Pickering-Brown SM
Thu Dec 01 00:00:00 UTC 2016
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
Human molecular genetics
Bennion Callister J,Ryan S,Sim J,Rollinson S,Pickering-Brown SM
Thu Dec 01 00:00:00 UTC 2016
Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size.
Human molecular genetics
Bennion Callister J,Ryan S,Sim J,Rollinson S,Pickering-Brown SM
Thu Dec 01 00:00:00 UTC 2016
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.
Acta neuropathologica
Cooper-Knock J,Higginbottom A,Stopford MJ,Highley JR,Ince PG,Wharton SB,Pickering-Brown S,Kirby J,Hautbergue GM,Shaw PJ
Wed Jul 01 00:00:00 UTC 2015
Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy.
Acta neuropathologica
Cooper-Knock J,Higginbottom A,Stopford MJ,Highley JR,Ince PG,Wharton SB,Pickering-Brown S,Kirby J,Hautbergue GM,Shaw PJ
Wed Jul 01 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers.
Acta neuropathologica
Mackenzie IR,Frick P,Grässer FA,Gendron TF,Petrucelli L,Cashman NR,Edbauer D,Kremmer E,Prudlo J,Troost D,Neumann M
Tue Dec 01 00:00:00 UTC 2015
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
Neuron
Wen X,Tan W,Westergard T,Krishnamurthy K,Markandaiah SS,Shi Y,Lin S,Shneider NA,Monaghan J,Pandey UB,Pasinelli P,Ichida JK,Trotti D
Wed Dec 17 00:00:00 UTC 2014
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
Neuron
Wen X,Tan W,Westergard T,Krishnamurthy K,Markandaiah SS,Shi Y,Lin S,Shneider NA,Monaghan J,Pandey UB,Pasinelli P,Ichida JK,Trotti D
Wed Dec 17 00:00:00 UTC 2014
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
Neuron
Wen X,Tan W,Westergard T,Krishnamurthy K,Markandaiah SS,Shi Y,Lin S,Shneider NA,Monaghan J,Pandey UB,Pasinelli P,Ichida JK,Trotti D
Wed Dec 17 00:00:00 UTC 2014
Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.
Neuron
Wen X,Tan W,Westergard T,Krishnamurthy K,Markandaiah SS,Shi Y,Lin S,Shneider NA,Monaghan J,Pandey UB,Pasinelli P,Ichida JK,Trotti D
Wed Dec 17 00:00:00 UTC 2014
