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Invitrogen
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Immunogen sequence: LRGEDKAATS DSELNEPLLA PVESNDSEDT PSKLFGARGN PALSDPGTPD QHQASQTHPP FPVGPQPLLT AQQLASAVAG VMPGGPPALN QPILIPFNMA GQLGGQQGLV LTLPTANLTN IQGLVAAAAA GGIMTLPLQN LQAT
Highest antigen sequence identity to the following orthologs: Mouse - 72%, Rat - 26%.
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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